To fill the massive void left by both wingers, Cassidy will turn to Tomas Nosek to fill Pastrnak's shoes on the second line, while veteran Nick Foligno will get a bump from the fourth to the third unit to take over for Frederic.
On the backend, Derek Forbort slides in for Josh Brown alongside Mike Reilly on the third pairing, while Jeremy Swayman takes over for Linus Ullmark between the pipes.
Detroit, who sits fifth in the Atlantic Division, has lost two straight games while the Bruins are currently enjoying a three-game win streak.