Ullmark signed a four-year, $20 million contract with the Bruins on July 28th, 2021. He made his regular season debut on October 22nd, which was a 4–1 win against his former team, the Buffalo Sabres.
The Swede appeared in 41 games this past season and posted a record of 26-10-2, with a 2.45 goals-against-average, a .917 save percentage and one shutout.