The Panthers (57-16-6) have a lot to play for as they are looking to clinch the franchise's first-ever Presidents' Trophy with a win.
On the flip side, the Bruins (49-25-5) are looking to push their latest win streak to three games, so they won't be an easy prey.
These teams crossed paths twice this season, but had very different looking lineups with both of those games happening a while ago.
The B's topped the Cats 3-2 at home all the way back on October 30, just three days after dropping a 4-1 decision to them in Florida.
After a stellar 30-save performance against the Rangers this weekend, the Bruins are turning to Linus Ullmark (24-10-2) between the pipes for this one as well.
He'll get to face off against Russian netminder Sergei Bobrovsky (39-6-3), the NHL's hottest goalie on the road.
The good news for Boston is that both star players David Pastrnak and Hampus Lindholm will draw back into the lineup after resting during the Bruins second half of their back-to-back matchups on Sunday.
That means rookie forward Marc McLaughlin and defenseman Mike Reilly will be healthy scratches tonight.
With no other roster changes coming, here are the expected lines and combos for the Bruins:
Brad Marchand - Patrice Bergeron - Jake Debrusk
Taylor Hall - Erik Haula - David Pastrnak
Trent Frederic - Charlie Coyle - Craig Smith
Nick Foligno - Tomas Nosek - Curtis Lazar
Hampus Lindholm - Charlie McAvoy
Matthew Grzelcyk - Brandon Carlo
Derek Forbort - Connor Clifton
Linus Ullmark
Jeremy Swayman
Puck drop between the Atlantic Division rivals is scheduled for 7pm ET at Boston's TD Garden.